Exosomes DC-EX
Exosomes today represent a promising direction for the treatment, prevention, and rehabilitation of various diseases.
DC-EX exosomes have the therapeutic potential of mesenchymal stem cells, are easy to obtain, and can be stored for up to 2 years.
The fundamental basis for the therapeutic effects of DC-EX exosomes lies in their ability to transfer biological information—in the form of cytokines, peptides, and RNA—from stem cells to damaged cells.
DC-EX exosomes have theoretical advantages over intact MMSCs as a drug in the field of regenerative medicine.
DC-EX exosomes have the therapeutic potential of mesenchymal stem cells, are easy to obtain, and can be stored for up to 2 years.
The fundamental basis for the therapeutic effects of DC-EX exosomes lies in their ability to transfer biological information—in the form of cytokines, peptides, and RNA—from stem cells to damaged cells.
DC-EX exosomes have theoretical advantages over intact MMSCs as a drug in the field of regenerative medicine.
Number of patients
Number of patients
Total number of our patients using exosomes for treatment and prevention
(data as of December 2024)
Total number of our patients using exosomes for treatment and prevention
(data as of December 2024)
- 1647TOTAL
- 889Revitalization and treatment of diseases (intravenous)
- 758Orthopedics and Cosmetology (local injections)
Exosomes
Description of exosomes
Exosomes are microscopic extracellular vesicles secreted into the intercellular space by cells of various tissues. Exosomes contain signaling substances that "tell" neighboring cells what and when to do.
Exosomes derived from human mesenchymal stem cells from bone marrow are the active ingredient in DC-Ex.
Exosomes provide:
• Epigenetic reprogramming (activates reparative cycle signaling pathways). Thus, cells reorient themselves toward the process of restoring the microenvironment.
• Exosomes also affect regional progenitor cells, triggering a cascade of migration and recruitment of other cellular elements and their differentiation. Microcirculation and cellular immunity are restored in tissues. Undesirable inflammatory reactions are blocked.
Exosomes derived from human mesenchymal stem cells from bone marrow are the active ingredient in DC-Ex.
Exosomes provide:
• Epigenetic reprogramming (activates reparative cycle signaling pathways). Thus, cells reorient themselves toward the process of restoring the microenvironment.
• Exosomes also affect regional progenitor cells, triggering a cascade of migration and recruitment of other cellular elements and their differentiation. Microcirculation and cellular immunity are restored in tissues. Undesirable inflammatory reactions are blocked.
Exosomes consist of:
1. MicroRNA
2. Growth factors
3. Cytokines (signaling molecules)
4. Peptides
1. MicroRNA
2. Growth factors
3. Cytokines (signaling molecules)
4. Peptides
Exosome action:
1. Activation of regeneration
2. Reduction of inflammation, apoptosis (cell death), and fibrosis
3. Angiogenesis (growth of new capillaries)
4. Immunomodulation (stimulation or suppression)
1. Activation of regeneration
2. Reduction of inflammation, apoptosis (cell death), and fibrosis
3. Angiogenesis (growth of new capillaries)
4. Immunomodulation (stimulation or suppression)
Exosomes
Use of exosomes
1. Revitalization: increased performance; disease prevention; health maintenance; anti-aging therapy.
2. Treatment: diseases of the heart, lungs, brain and nervous system, liver, kidneys, autoimmune diseases, diabetes, infertility.
3. Orthopedics: joint and spine diseases, injuries.
4. Cosmetology: mesotherapy to slow down aging and promote healthy skin.
5. Urology: erectile dysfunction.
6. Dermatology: skin diseases.
7. Surgery: skin damage, burns, frostbite, purulent inflammation, etc.
8. Oncology
2. Treatment: diseases of the heart, lungs, brain and nervous system, liver, kidneys, autoimmune diseases, diabetes, infertility.
3. Orthopedics: joint and spine diseases, injuries.
4. Cosmetology: mesotherapy to slow down aging and promote healthy skin.
5. Urology: erectile dysfunction.
6. Dermatology: skin diseases.
7. Surgery: skin damage, burns, frostbite, purulent inflammation, etc.
8. Oncology
Exosomes
Comparison of exosomes with stem cells
The primary effect of donor stem cells is paracrine—that is, the expression of exosomes containing biologically active substances. Thus, donor stem cells exert their effects through exosomes. The use of exosomes from donor multipotent mesenchymal stem cells (MMSCs) can replace or complement the use of MMSCs.
In some cases, these effects have been clearly demonstrated to be as effective as the administration of whole-cell MMSCs. The fundamental basis for the therapeutic effects of exosomes lies in their ability to transfer biological information—in the form of proteins, glycoproteins, lipids, and ribonucleic acids—from stem cells to damaged cells.
Exosomes have theoretical advantages over intact MMSCs as a therapeutic agent and may in the future gain an advantage over whole cells in the field of regenerative medicine.
Exosomes are significantly less expensive than MMSCs. Unlike MMSCs, exosomes can be stored for a long time (up to 24 months).
In some cases, these effects have been clearly demonstrated to be as effective as the administration of whole-cell MMSCs. The fundamental basis for the therapeutic effects of exosomes lies in their ability to transfer biological information—in the form of proteins, glycoproteins, lipids, and ribonucleic acids—from stem cells to damaged cells.
Exosomes have theoretical advantages over intact MMSCs as a therapeutic agent and may in the future gain an advantage over whole cells in the field of regenerative medicine.
Exosomes are significantly less expensive than MMSCs. Unlike MMSCs, exosomes can be stored for a long time (up to 24 months).
Exosomes
Benefits of DC-EX exosomes
- Derived from bone marrow mesenchymal stem cells
- High exosome concentration – 12 trillion per ml
- High therapeutic activity
- Long shelf life (up to 2 years):
- High exosome concentration – 12 trillion per ml
- High therapeutic activity
- Long shelf life (up to 2 years):
DC-EX Exosome Composition:
- Number of exosomes per ml: 10 to 18 trillion
- Exosome size: 50-60 nm
- Cytokines (signaling molecules)
- 64 growth factors
- Over 1000 microRNAs
Content of growth factors in DC-EX exosomes
Exosomes
Types and packaging of DC-EX exosomes:
- DC-Ex-V-5, 10, 20 ml – for intravenous use (anti-aging therapy, disease treatment, performance support). Exosome concentration: 10-18 trillion/ml.
- DC-Ex-L - 5 ml – for local injections (orthopedics, cosmetology, urology, surgery). Exosome concentration: 10-14 trillion/ml.
- DC-Ex-P – lyophilized powder with exosomes for intravenous and local injections. Must be diluted with saline before administration. Exosome concentration: 44 trillion/vial.
- DC-Ex-N - 2 ml – drops for intranasal use (anti-aging therapy, disease treatment, performance support). Exosome concentration: 2.5 trillion/ml.
- DC-Ex-S – 20 ml – spray for external use (cosmetology, dermatology, surgery). Exosome concentration: 1.7 trillion/ml.
- DC-Ex-G – 10 ml – gel – for external use (dermatology, orthopedics, surgery). Exosome concentration: 2.5 trillion/ml.
Exosomes
Certificates:
DOKAR VITA CELLS COMPANY
About company
Dokar Vita Cells — an international company whose main activities are:
1. Organization and oversight of the production of cellular products (allogeneic multipotent mesenchymal stem cells from bone marrow (BM-MMSCs), DC-Ex exosomes, NK cells, oncolytic viruses, etc.) in our own and partner laboratories.
2. Organization of treatment with cellular products (BM-MMSCs, exosomes, NK cells, oncolytic viruses) in partner clinics in Russia, Europe, Thailand, and Vietnam.
3. Organization of training for physicians in cellular technologies.
1. Organization and oversight of the production of cellular products (allogeneic multipotent mesenchymal stem cells from bone marrow (BM-MMSCs), DC-Ex exosomes, NK cells, oncolytic viruses, etc.) in our own and partner laboratories.
2. Organization of treatment with cellular products (BM-MMSCs, exosomes, NK cells, oncolytic viruses) in partner clinics in Russia, Europe, Thailand, and Vietnam.
3. Organization of training for physicians in cellular technologies.
DOKAR VITA CELLS COMPANY
LAB-1
Closed research laboratory of cellular technologies.
• Production of cell cultures from human bone marrow and umbilical cord blood
• Production of allogeneic NK cells
• Research activities
• Experimental activities
• Production of cell cultures from human bone marrow and umbilical cord blood
• Production of allogeneic NK cells
• Research activities
• Experimental activities
DOKAR VITA CELLS COMPANY
LAB-3
Private research laboratory of cellular technologies.
•Production of cell cultures from bone marrow
•Research activities
•Experimental activities
•Production of cell cultures from bone marrow
•Research activities
•Experimental activities
DOKAR VITA CELLS COMPANY
Exosome production
There are three main methods for producing exosomes:
- Differential ultracentrifugation (DUC)
- Density gradient ultracentrifugation
- Ultrafiltration
We use our own ultrafiltration method.
During the MMSC cultivation process, exosomes are isolated into a nutrient medium. After MMSC isolation, a solution containing exosomes (supernatant) remains in the cultivation chamber.
The supernatant is then filtered and concentrated (5 or 10 times), and packaged.
DOKAR Laboratory has developed its own exosome production technology—triple filtration and concentration.
We use 0.22 and 0.45 µm filters and dialysis cartridges.
We have created our own exosome concentration system.
Use of exosomes
Treatment programs with exosomes
Program 1 - REVITALIZATION
The revitalization program is used to improve performance, prevent disease, support health and well-being, and for anti-aging therapy. Exosomes are administered intravenously.
Order or ask a question Program 2 - TREATMENT
The program is used to treat most diseases of the heart, lungs, liver, kidneys, central and peripheral nervous system, diabetes, autoimmune diseases, etc. A course of intravenous exosome administration is administered.
Order or ask a question Program 3 - ORTHOPEDICS
The program is used to treat diseases and injuries of the joints and spine. It involves local administration of exosomes and taping.
Order or ask a question Program 4 - COSMETOLOGY
The program is used for mesotherapy (facial injections) to reduce and prevent signs of facial aging. Localized exosome injections and taping are performed.
Order or ask a question Program 5 - UROLOGY
The program is used to treat erectile dysfunction and pelvic pain. It involves local administration of exosomes.
Order or ask a question Program 6 - DERMATOLOGY
The program is used to treat skin diseases and injuries. It is performed using exosome solutions.
Order or ask a question Program 7 - SURGERY
The program is used to accelerate recovery after surgery. It utilizes intravenous infusion and local applications of an exosome solution.
Order or ask a question Program 8 - SPORT
The program is used to increase endurance and accelerate recovery after training, competitions, and injuries. It utilizes intravenous infusions and local injections of the exosome preparations DC-EX-V and DC-EX-L.
Order or ask a question Your question
Just write your question and we will answer as soon as possible.
DC-EX ORDER
To order DC-EX exosomal products, please text us to email: dokartest@gmail.com
Text to us
dokartest@gmail.com
